Serious adverse reactions, including excessive weakness, dysphagia, and aspiration pneumonia, with some adverse reactions associated with fatal outcomes, have been reported in patients who received BOTOX injections for unapproved uses. In these cases, the adverse reactions were not necessarily related to distant spread of toxin, but may have resulted from the administration of BOTOX to the sitio of injection and/or adjacent structures.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Botox only for the indication prescribed.
Allow the area to dry, then lightly sprinkle the area with starch powder. Gently blow off any excess starch powder. The hyperhidrotic area will develop a deep blue-black color over approximately 10 minutes. Each injection site has a ring of effect of up to approximately 2 cm in diameter. To minimize the area of pelo effect, the injection sites should be evenly spaced as shown in Figure seis.
These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity but symptoms can also occur in adults, particularly in those patients who have an underlying condition that would predispose them to these symptoms. (5.1)
Muscle Strength and Mass: Individuals with stronger or larger facial muscles (often, but not always, correlating with male patients) will typically need more units to achieve the desired relaxation compared to those with weaker or smaller muscles.
OnabotulinumtoxinA is a neurotoxin that works by temporarily blocking the release of acetylcholine, a neurotransmitter responsible for triggering muscle contraction or gland secretion. Depending on the specific condition being treated, this can:
Below is a breakdown of typical unit ranges for the most common facial and neck areas using Botox Cosmetic:
OnabotulinumtoxinA may cause loss of strength or general muscle weakness, vision problems, or dizziness within hours to weeks of receiving Botox or Botox Cosmetic. If this happens, do not drive a car, operate machinery, or do other dangerous activities.
Botox Cosmetic is used for aesthetic purposes for wrinkles and Botox is used as a therapeutic treatment for different medical conditions, including migraine headache prevention.
Subsequent doses for patients experiencing incomplete paralysis of the target muscle may be increased up botox to two-fold compared to the previously administered dose.
If patient’s body weight is greater than or equal to 34 kg, the recommended dosage is 200 Units of BOTOX per treatment administered as an intradetrusor injection after dilution: Reconstitute BOTOX to result in 20 Units BOTOX/mL in the vial(s):
Tell your health care provider if you are taking blood thinners or medicines that can interfere with the clotting of blood, such as aspirin or warfarin. These medicines might make it more likely that you will experience bruising or bleeding at the injection site.
You should minimize strenuous activity and avoid extensive sun or heat exposure for about 24 hours after treatment and until any swelling or redness has resolved.
The initial listed doses of the reconstituted BOTOX typically create paralysis of the injected muscles beginning one to two days after injection and increasing in intensity during the first week. The paralysis lasts for 2-6 weeks and gradually resolves over a similar time period.